Stress-Mediated Attenuation of Translation Undermines T-cell Activity in Cancer.
Brian P RiesenbergElizabeth G HuntMegan D TennantKatie E HurstAlex M AndrewsLee R LeddyDavid M NeskeyElizabeth G HillGuillermo O Rangel RiveraChrystal M PaulosPeng GaoJessica E ThaxtonPublished in: Cancer research (2022)
Proteasome function is a necessary cellular component for endowing T cells with tumor killing capacity by mitigating translation attenuation resulting from the unfolded protein response induced by stress in the tumor microenvironment.