Analysis of rare variants of autosomal-dominant genes in a Chinese population with sporadic Parkinson's disease.

Ran ZhengChong-Yao JinYing ChenYang RuanTing GaoZhi-Hao LinJia-Xian DongYa-Ping YanJun TianJia-Li PuBao-Rong Zhang

Published in: Molecular genetics & genomic medicine (2020)

Our results confirm the strong impact of LRRK2 on the risk of sporadic PD, and also provide considerable evidence of the existence of additional undetermined rare variants in AD-PD genes that contribute to the genetic etiology of sporadic PD in a Chinese cohort.

Keyphrases

late onset
genome wide
copy number
amyotrophic lateral sclerosis
dna methylation
bioinformatics analysis
genome wide identification
gene expression
genome wide analysis