The possible effects of the MTOR polymorphisms on preeclampsia susceptibility, severity, and onset: a case-control study and in silico analysis.

Mahnaz RezaeiMarzieh GhasemiMohsen SaravaniFatemeh GhahghayiHossein Shahraki-GhadimSaeedeh Salimi

Published in: Molecular biology reports (2024)

The MTOR rs17036508T/C polymorphism was associated with PE risk. There was an association between the MTOR rs2295080 variant and an increased risk of EOPE. The MTOR rs17036508T/C and rs2295080T/C variants could disrupt several binding motifs and TFII-I binding respectively.

Keyphrases

cell proliferation
early onset
dna binding
molecular docking
copy number
gene expression
binding protein
dna methylation