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Multivalency-enhanced enzyme inhibitors with biomolecule-responsive activity.

Fan DingXinrui LiXu ChenYue MaGuoqing Pan
Published in: Biomaterials science (2023)
This work reports a polymeric adenosine triphosphate (ATP)-responsive trypsin inhibitor. The polymeric inhibitor was rationally obtained by optimizing the benzamidine and phenylboronic acid monomers, which could synergistically bind with the phosphate and ribose groups in ATP. The ATP-responsive trypsin activity shows its potential as a therapeutic drug for cancer-targeting cell inhibition.
Keyphrases
  • cancer therapy
  • drug delivery
  • papillary thyroid
  • single cell
  • adverse drug
  • drug release
  • squamous cell carcinoma
  • squamous cell
  • stem cells
  • mesenchymal stem cells
  • protein kinase