Epithelial CRL4 DCAF2 Is Critical for Maintaining Intestinal Homeostasis Against DSS-Induced Colitis by Regulating the Proliferation and Repair of Intestinal Epithelial Cells.
Yu ZhangChaohui WangLexi WuChenhao BaiKaituo HuangLingya YaoZhou ZhangLingna YeRongbei LiuXiaolong GeMengque XuYuan ZhaoQian CaoPublished in: Digestive diseases and sciences (2023)
downregulation in IECs promotes intestinal barrier dysfunction and inhibits IEC proliferation, thus making it more susceptible to inflammation.