Altered metabolic pathways in a transgenic mouse model suggest mechanistic role of amyloid precursor protein overexpression in Alzheimer's disease.

Hattapark Dejakaisaya Anna Harutyunyan Patrick Kwan Nigel Charles Jones

Published in: Metabolomics : Official journal of the Metabolomic Society (2021)

Changes in metabolite concentrations and metabolic pathways are present in the early stage of APP pathology, and may be important for AD development and progression.

Keyphrases

early stage
mouse model
cell proliferation
cognitive decline
transcription factor
protein protein
sentinel lymph node
binding protein
radiation therapy
mild cognitive impairment
small molecule