Integrin αvβ3 Receptor Overexpressing on Tumor-Targeted Positive MRI-Guided Chemotherapy.
Renuka KhatikZhengyun WangDebo ZhiSonia KiranPankaj DwivediGaolin LiangBensheng QiuQing YangPublished in: ACS applied materials & interfaces (2019)
Multifunctional nanomaterials with targeted imaging and chemotherapy have high demand with great challenge. Herein, we rationally aimed to design multifunctional drug delivery systems by RGD-modified chitosan (CH)-coated nanoneedles (NDs) of gadolinium arsenate (RGD-CH-Gd-AsNDs). These NDs have multifunctionality for imaging and targeted therapy. NDs on intravenous administration demonstrated significant accumulation of As ions/species in tumor tissues, which was monitored by the change in T1-weighted magnetic resonance (MR) imaging. Moreover, NDs were well opsonized in cells with high specificity, subsequently inducing apoptosis to the HepG2 cells. Consequent to this, the in vivo results demonstrated biosafety, enhanced tumor targeting, and tumor regression in a subcutaneously transplanted xenograft model in nude mice. These RGD-CH-Gd-AsNDs have great potential, and we anticipate that they could serve as a novel platform for real-time T1-weighted MR diagnosis and chemotherapy.
Keyphrases
- contrast enhanced
- magnetic resonance
- cancer therapy
- drug delivery
- magnetic resonance imaging
- locally advanced
- cell cycle arrest
- gene expression
- computed tomography
- type diabetes
- risk assessment
- metabolic syndrome
- insulin resistance
- adipose tissue
- endoplasmic reticulum stress
- network analysis
- mass spectrometry
- skeletal muscle
- cell proliferation
- human health
- fluorescence imaging
- signaling pathway
- wild type