NBCn1 Increases NH4 + Reabsorption Across Thick Ascending Limbs, the Capacity for Urinary NH4 + Excretion, and Early Recovery from Metabolic Acidosis.
Jeppe S M OlsenSamuel SvendsenPeder BergVibeke S DamMads Vaarby SorensenVladimir V MatchkovJens LeipzigerDonna M B BoedtkjerPublished in: Journal of the American Society of Nephrology : JASN (2021)
During metabolic acidosis, NBCn1 is required for the upregulated basolateral HCO3 - uptake and transepithelial NH4 + reabsorption in mTALs, renal medullary NH4 + accumulation, urinary NH4 + excretion, and early recovery of arterial blood pH and standard [HCO3 -]. These findings support that NBCn1 facilitates urinary net acid excretion by neutralizing intracellular H+ released during NH4 + reabsorption across mTALs.