T cell-mediated targeted delivery of tadalafil regulates immunosuppression and polyamine metabolism to overcome immune checkpoint blockade resistance in hepatocellular carcinoma.

Xiaobin WangQiaoyun ZhangJingwen ZhouZecong XiaoJianxin LiuShaohui DengXiaoyang HongWensou HuangMingyue CaiYongjian GuoJingjun HuangYong WangLiteng LinKang-Shun Zhu

Published in: Journal for immunotherapy of cancer (2023)

Our novel tumor-targeted nanodrug expands the application of TA in tumor therapy and holds great potential to break the logjam of ICB-based HCC immunotherapy.

Keyphrases

cancer therapy
drug delivery
benign prostatic hyperplasia
cell therapy
replacement therapy