Estradiol Valerate vs Ethinylestradiol in Combined Oral Contraceptives: Effects on the Pituitary-Ovarian Axis.

Annina H Haverinen Kaisu Luiro Marika H Kangasniemi Annemieke HoekSteinar HustadOskari Heikinheimo Juha S Tapanainen

Published in: The Journal of clinical endocrinology and metabolism (2022)

Compared with EE + DNG, treatment with EV + DNG resulted in milder pituitary downregulation and reduced induction of hepatic SHBG synthesis-potentially carrying more beneficial health effects.

Keyphrases

growth hormone
cell proliferation
signaling pathway
combination therapy
estrogen receptor