Effects of genetic background, sex, and age on murine atrial electrophysiology.

Julius Obergassel Molly O'Reilly Laura C Sommerfeld Syeeda Nashitha Kabir Christopher O'SheaFahima SyedaLars EckardtPaulus F Kirchhof Larissa Fabritz

Published in: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology (2021)

This work defines normal ranges for murine atrial EP parameters. Genetic background has a profound effect on these parameters, at least of the magnitude as those of sex and age. These results can inform the experimental design and interpretation of murine atrial electrophysiology.

Keyphrases

atrial fibrillation
left atrial
catheter ablation
genome wide
copy number
intellectual disability
heart failure
autism spectrum disorder
mitral valve