Serum neurofilament heavy chains as early marker of motor neuron degeneration.
Maxim De SchaepdryverJanne GoossensSteffi De MeyerAndreas JerominPegah MasroriBritta BrixKristl G ClaeysJolien SchaeverbekeKatarzyna AdamczukRik VandenberghePhilip Van DammeKoen PoesenPublished in: Annals of clinical and translational neurology (2019)
Our findings demonstrate that serum pNfH is elevated well before the time of diagnosis in mainly sporadic ALS patients. These results encourage to prospectively explore if pNfH has an added value to shorten the diagnostic delay in ALS.