Discovery and validation of plasma, saliva and multi-fluid plasma-saliva metabolomic scores predicting insulin resistance and diabetes progression or regression among Puerto Rican adults.

Danielle E HaslamLiming LiangKai GuoMarijulie Martínez-LozanoCynthia M PérezChih-Hao LeeEvangelia Morou-BermudezClary ClishDavid T W WongJoAnn E MansonFrank B HuMeir J StampferKaumudi JoshipuraShilpa N Bhupathiraju

Published in: Diabetologia (2024)

The plasma metabolomic score predicting insulin resistance was more strongly associated with incident type 2 diabetes than the saliva metabolomic score. Only the saliva metabolomic score was associated with incident prediabetes.

Keyphrases

type diabetes
insulin resistance
cardiovascular disease
glycemic control
adipose tissue
metabolic syndrome
high fat diet
polycystic ovary syndrome
skeletal muscle