Fatigued Patients with Chronic Liver Disease Have Subtle Aberrations of Sleep, Melatonin and Cortisol Circadian Rhythms.

Michele M TanaHawwa AlaoNevitt MorrisShanna BernsteinJacob HattenbachRahiya B RehmanRobert BrychtaSouvik SarkarXiongce ZhaoMary WalterAshura BuckleyKong ChenYaron Rotman

Published in: Fatigue : biomedicine, health & behavior (2017)

Subtle aberrations in melatonin and adrenal circadian rhythms, as well as reduced sleep efficiency, likely contribute to fatigue in patients with CLD. These abnormalities may ultimately be a therapeutic target to improve quality of life for fatigued patients with CLD.

Keyphrases

sleep quality
copy number
physical activity
depressive symptoms
gene expression