Gender differences in juvenile systemic sclerosis patients: Results from the international juvenile scleroderma inception cohort.
Ivan FoeldvariJens KlotscheOzgur KasapcopurAmra AdrovicMaria Teresa TerreriAna Paula SakamotoValda StanevichaJordi AntónBrian M FeldmanFlavio SztajnbokRaju KhubchandaniEkaterina AlexeevaMaria KatsicasSujata SawhneyVanessa SmithSimone AppenzellerTadej AvcinMikhail KostikThomas LehmanEdoardo MarraniDieneke Schonenberg-MeinemaWalter-Alberto Sifuentes-GiraldoNatalia Vasquez-CanizaresMahesh JanarthananMonika MollDana NemcovaAnjali PatwardhanMaria Jose SantosCristina BattagliottiLillemor BerntsonBlanca BicaJürgen BrunnerRolando CimazPatricia Costa-ReisDespina EleftheriouLiora HarelGerd HorneffSindhu R JohnsonDaniela KaiserTilmann KallinichDragana LazarevicKirsten MindenSusan NielsenFarzana NuruzzamanSiri Opsahl HetlevikYosef UzielNicola HelmusKathryn S TorokPublished in: Journal of scleroderma and related disorders (2022)
In this cohort, juvenile onset systemic sclerosis had a more severe course in males at baseline and but the pattern changed after 12 months. Some differences from adult findings persisted, there is no increased signal of pulmonary arterial hypertension or heart failure in male pediatric patients. While monitoring protocols of organ involvement in juvenile onset systemic sclerosis need to be identical for males and females.