Downregulation of CD73 associates with T cell exhaustion in AML patients.

Yaxian KongBei JiaChenchen ZhaoDavid F ClaxtonArati SharmaCharyguly AnnageldiyevJoseph S FotosHui ZengRobert F PaulsonK Sandeep PrabhuHong Zheng

Published in: Journal of hematology & oncology (2019)

Our data highlight the potential of CD73 as a double-edged sword in anti-leukemia immunity and argue strongly for the combinational treatment by adding immune checkpoint inhibitors to the CD73-targeting approaches.

Keyphrases

end stage renal disease
acute myeloid leukemia
newly diagnosed
ejection fraction
chronic kidney disease
nk cells
prognostic factors
cell proliferation
peritoneal dialysis
big data
machine learning
acute lymphoblastic leukemia