Placental transfer of NMDAR antibodies causes reversible alterations in mice.

Anna García-SerraMarija RadosevicAnika PupakVeronica BritoJosé RíosEsther AguilarEstibaliz MaudesHelena AriñoMarianna SpatolaFrancesco MannaraMarta PedreñoBastien JoubertSilvia GinésJesús PlanagumàJosep O Dalmau

Published in: Neurology(R) neuroimmunology & neuroinflammation (2020)

In this model, placental transfer of patients' NMDAR antibodies caused severe but reversible synaptic and neurodevelopmental alterations. Reversible antibody effects may contribute to the infrequent and limited number of complications described in children of patients who develop anti-NMDAR encephalitis during pregnancy.

Keyphrases

end stage renal disease
newly diagnosed
ejection fraction
chronic kidney disease
peritoneal dialysis
prognostic factors
risk factors
early onset
type diabetes
skeletal muscle
patient reported outcomes