Serum checkpoint molecules in patients with IgG4-related disease (IgG4-RD).

Haruki MatsumotoYuya FujitaNaoki MatsuokaJumpei TemmokuMakiko Yashiro-FuruyaTomoyuki AsanoShuzo SatoHiroshi WatanabeEiji SuzukiSosuke TsujiShoichi FukuiMasataka UmedaNaoki IwamotoAtsushi KawakamiKiyoshi Migita

Published in: Arthritis research & therapy (2021)

Serum levels of Gal-9 and sTIM-3 were significantly elevated in untreated patients with IgG4-RD. Furthermore, serum levels of sTIM-3 were significantly higher in IgG4-RD patients with visceral involvements. These checkpoint molecules could be a potentially useful biomarker for IgG4-RD and for assessing the clinical phenotypes of IgG4-RD.

Keyphrases

dna damage
cell cycle
type diabetes
insulin resistance
cell proliferation
oxidative stress