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KI04 an Aminoglycosides-Derived Molecule Acts as an Inhibitor of Human Connexin46 Hemichannels Expressed in HeLa Cells.

Cheng-Wei Tom ChangNaveena PoudyalDaniel A VerdugoFrancisca PeñaJimmy StehbergMauricio Antonio Retamal
Published in: Biomolecules (2023)
These results demonstrate that KI04 could be used as a Cx46 inhibitor and could help to develop future selective Cx46 inhibitors.
Keyphrases
  • cell cycle arrest
  • induced apoptosis
  • endothelial cells
  • neoadjuvant chemotherapy
  • cell death
  • current status
  • pi k akt
  • endoplasmic reticulum stress
  • signaling pathway
  • oxidative stress