Silencing of interferon regulatory factor gene 6 in melanoma.

Published in: PloS one (2017)

IRF6 is aberrantly silenced by DNA methylation of the 5' IRF6 CGI in melanoma. The methylation status of IRF6 is potentially associated with the sensitivity of melanoma to interferon.

Keyphrases

dendritic cells
dna methylation
genome wide
skin cancer
gene expression
copy number
immune response
basal cell carcinoma
transcription factor