Assessment of the toxicity and carcinogenicity of double-walled carbon nanotubes in the rat lung after intratracheal instillation: a two-year study.
Dina Mourad SalehShengyong LuoOmnia Hosny Mohamed AhmedDavid B AlexanderWilliam T AlexanderSivagami GunasekaranAhmed M El-GazzarMohamed AbdelgiedTakamasa NumanoHiroshi TakaseMakoto OhnishiSusumu TomonoRanda Hussein Abd El HadyKatsumi FukamachiJun KannoAkihiko HiroseJiegou XuShugo SuzukiAya Naiki-ItoSatoru TakahashiHiroyuki TsudaPublished in: Particle and fibre toxicology (2022)
Our results demonstrate that the DWCNT fibers we tested are biopersistent in the rat lung and induce chronic inflammation. Rats treated with 0.5 mg DWCNT developed pleural fibrosis and lung tumors. These findings demonstrate that the possibility that at least some types of DWCNTs are fibrogenic and tumorigenic cannot be ignored.
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