TRAF4 Maintains Deubiquitination of Caveolin-1 to Drive Glioblastoma Stemness and Temozolomide Resistance.
Yongxu LiTiepeng WangQuan WanQing WangZhenzhong ChenYuan GaoYuchen YeJiusheng LinBihuan ZhaoHuaile WangJinming YangKai ZhaoNa LuPublished in: Cancer research (2022)
The identification of a TRAF4/Caveolin-1 axis that plays a crucial role in malignant progression of glioblastoma provides new insights into the function of TRAF4 in ubiquitin signaling and suggests TRAF4 as a potential therapeutic target.