Assessment of the targeted effect of Sijunzi decoction on the colorectal cancer microenvironment via the ESTIMATE algorithm.

Jiaxin DuQuyuan TaoYing LiuZhanming HuangHe JinWenjia LinXinying HuangJingyan ZengYongchang ZhaoLingyu LiuQian XuXue HanLixia ChenXin-Lin ChenYi Wen

Published in: PloS one (2022)

The core genes (HSPB1, SPP1, IGFBP3 and TGFB1) affected CRC development and prognosis by regulating hypoxia, protein binding and epithelial-mesenchymal transition in the extracellular matrix.

Keyphrases

extracellular matrix
epithelial mesenchymal transition
transforming growth factor
machine learning
binding protein
heat shock protein
stem cells
genome wide
deep learning
signaling pathway
cancer therapy
endothelial cells
heat shock
protein protein
amino acid
dna binding
gene expression
neural network
drug delivery