Integrative Single-Cell Analysis of Cardiomyopathy Identifies Differences in Cell Stemness and Transcriptional Regulatory Networks among Fibroblast Subpopulations.
Wenyang NieZhi-Jie ZhaoYuhang LiuYoucao WangJingwen ZhangYing HuYang LiuYong WangZhen WangPublished in: Cardiology research and practice (2024)
C3 AGT + Fibroblasts exhibit increased sensitivity towards adverse outcomes in cardiomyopathy, such as myocardial fibrosis and impaired cardiac contractile function, compared to other cardiac fibroblast subpopulations. The differential cellular plasticity and transcriptional regulatory activity between C3 AGT + Fibroblasts and other subgroups offer new perspectives for targeting fibroblast subpopulation activity to treat cardiomyopathy. Additionally, stemness genes EPAS1 and MYC, along with the regulator FOS, may play roles in modulating the biological processes of cardiac fibroblasts in cardiomyopathy.
Keyphrases
- transcription factor
- single cell
- left ventricular
- heart failure
- stem cells
- extracellular matrix
- epithelial mesenchymal transition
- genome wide
- rna seq
- gene expression
- signaling pathway
- skeletal muscle
- genome wide identification
- cell therapy
- wound healing
- dna methylation
- heat shock
- mesenchymal stem cells
- atrial fibrillation
- bone marrow