A killer metamorphosis: catching BAK in action at the membrane.

Published in: The EMBO journal (2021)

Permeabilization of the outer mitochondrial membrane initiates apoptotic cell death. B-cell lymphoma 2 (BCL-2) antagonist killer (BAK) and BCL-2-associated X (BAX) mediate mitochondrial poration, but how this process unfolds remains poorly defined. Two studies in this issue investigate the transition of dormant, inactive BAK monomer to a highly dynamic membrane-associated, pore-forming oligomer.

Keyphrases

cell death
oxidative stress
diffuse large b cell lymphoma
induced apoptosis
cell proliferation
signaling pathway
anti inflammatory
high resolution
molecularly imprinted