Tuning phosphorene and MoS 2 2D materials for detecting volatile organic compounds associated with respiratory diseases.
Alaa AlloshCalin-Andrei Pantis-SimutNicolae FilipoiuAmanda Teodora PredaGeorge NeculaIoan GhitiuDragos-Victor AnghelMihnea Alexandru DuleaGeorge Alexandru NemnesPublished in: RSC advances (2024)
Efficient identification of volatile organic compounds (VOCs) is essential for the rapid diagnostication of respiratory diseases. By detecting specific biomarkers associated with different pathologies one may distinguish between tuberculosis, nosocomial pneumonia, Aspergillus fumigatus , influenza and SARS-CoV-2 virus infections. Phosphorene and MoS 2 are potential candidates from the class of 2D graphene-like materials, which can be used as active layers for sensing elements. However, as the target molecules poorly adhere to the pristine layers, binding centers are created by introducing substitutional impurities. The adsorbed VOCs induce modifications in the electrical properties of the customized active layers. For each biomarker and a sequence of substitutional impurities, a pattern of conductivities is obtained, which enables the detection of an unknown test specimen. Exploring multiple biosensor configurations we find an optimal design yielding a considerable selectivity for the five biomarker compounds.
Keyphrases
- quantum dots
- sars cov
- loop mediated isothermal amplification
- room temperature
- solar cells
- label free
- sensitive detection
- mycobacterium tuberculosis
- reduced graphene oxide
- emergency department
- respiratory syndrome coronavirus
- pulmonary tuberculosis
- walled carbon nanotubes
- hiv aids
- highly efficient
- visible light
- klebsiella pneumoniae
- human health
- hepatitis c virus
- binding protein
- cystic fibrosis
- escherichia coli
- bioinformatics analysis
- electronic health record
- amino acid
- structural basis
- climate change