Early Versus Late Initiation of Renal Replacement Therapy in Critically Ill Patients: Systematic Review and Meta-Analysis.
Bruno Adler Maccagnan Pinheiro BesenThiago Gomes RomanoPedro Vitale MendesCesar Albuquerque GalloFernando Godinho ZampieriAntonio Paulo NassarMarcelo ParkPublished in: Journal of intensive care medicine (2017)
Pooled analysis of randomized trials indicates early initiation of RRT is not associated with lower mortality rates. The potential benefit of reduced mortality associated with early initiation of RRT was limited to low-quality observational studies.