Children with sickle cell disease and severe COVID-19 presenting single nucleotide polymorphisms in innate immune response genes - A case report.
Natália Lima PessoaLilian Martins Oliveira DinizAdriana de Souza AndradeErna Geessien KroonAline Almeida BentesMarco Antônio CamposPublished in: EJHaem (2021)
Here we report three clinical cases of children with sickle cell disease (SCD) and severe COVID-19 who evolved with complications during hospitalization or after discharge. They present single nucleotide polymorphisms in tlr-7 and tirap genes, identified from 37 patients under 16 years old hospitalized from September 2020 to May 2021 in the Hospital João Paulo II, Belo Horizonte, Brazil. They presented significant complications of SCD as acute chest syndrome, splenic sequestration, and pain crisis during hospitalization or up to 2 months after SARS-CoV-2 infection. They all required transfusion of concentrated red blood cells and hospitalization in a reference hospital to care for children with SCD.
Keyphrases
- coronavirus disease
- young adults
- healthcare
- sars cov
- innate immune
- red blood cell
- end stage renal disease
- genome wide
- public health
- risk factors
- toll like receptor
- chronic kidney disease
- early onset
- newly diagnosed
- respiratory syndrome coronavirus
- pain management
- emergency department
- cardiac surgery
- prognostic factors
- peritoneal dialysis
- dna methylation
- spinal cord
- respiratory failure
- bioinformatics analysis
- health insurance
- neuropathic pain
- nuclear factor
- transcription factor
- acute kidney injury
- patient reported
- mechanical ventilation