[Molecular epidemiological analysis of hiv infection in northern seaports of Russia].
E V KazennovaV Yu LagaK B GromovM N SankovE S PopovaE G LgumnovaE N OparinaT A SorokinaMarina BobkovaPublished in: Voprosy virusologii (2018)
The results of the molecular-epidemiological analysis of HIV-1 variants circulating in Arkhangelsk and Murmansk - northern seaports of Russia - were presented. In these seaports the HIV-1 variants belonging to subtype A1 were predominant (93% in Murmansk, 83% in Arkhangelsk). In addition to these variants, viruses of other subtypes such as B, C, D and recombinant forms CRF02_AG and CRF03_AB were identifed. The heterogeneity of circulating HIV-1 variants was higher in Arkhangelsk than in Murmansk. According to the results of phylogenetic analysis, subtype A1 sequences formed the common branch with nucleotide sequences of IDU-A strains found in other regions of Russia. HIV-1 variants of subtype B sub-clustered with sequences of East European B-variants. The recombinant strains CRF02_AG formed the common branch with HIV-1 sequences from Central Asia republics of the former USSR. Among 124 therapy-naive patients from Arkhangelsk and Murmansk (n = 124) the transmitted resistance was less than 5%.
Keyphrases
- antiretroviral therapy
- hiv infected
- hiv positive
- hiv testing
- copy number
- human immunodeficiency virus
- hiv aids
- hepatitis c virus
- men who have sex with men
- escherichia coli
- end stage renal disease
- south africa
- chronic kidney disease
- quantum dots
- newly diagnosed
- gene expression
- ejection fraction
- single cell
- single molecule