A switch-variant model integrates the functions of an autoimmune variant of the phosphatase PTPN22.

Torkel VangJimmi NielsenGarth Lawrence Burn

Published in: Science signaling (2018)

The R620W polymorphism in protein tyrosine phosphatase nonreceptor type 22 (PTPN22) predisposes carriers to several autoimmune diseases. Two papers in Science Immunology and Science Signaling on this human disease-associated variant lead us to propose a new "switch-of-function" model.

Keyphrases

public health
endothelial cells
multiple sclerosis
induced pluripotent stem cells
protein protein
small molecule
drug induced