Soluble fibrinogen-like protein 2 promotes the growth of hepatocellular carcinoma via attenuating dendritic cell-mediated cytotoxic T cell activity.

Muyang YangZhongwei ZhangJiajia ChenMengying XuJiaquan HuangMing WangWeina LiXiaoyang WanMan-Fung YuenXiaoping LuoDong XiQin Ning

Published in: Journal of experimental & clinical cancer research : CR (2019)

Our data suggest that sFGL2 promotes hepatoma growth by attenuating DC activity and subsequent CD8+ T cell cytotoxicity, suggesting sFGL2 as a novel potential therapeutic target for HCC treatment.

Keyphrases

dendritic cells
regulatory t cells
electronic health record
immune response
big data
combination therapy
climate change
human health