Trilobatin attenuates cerebral ischemia/reperfusion-induced blood-brain-barrier dysfunction by targeting MMP9: The legend of a food additive.
Linying FengYeli LiMu LinDianyou XieYunmei LuoYuandong ZhangZhixu HeQihai GongQiu-Yan ZhangJianmei GaoPublished in: British journal of pharmacology (2023)
Our findings reveal a novel property of TLB: saving BBB disruption following cerebral I/R via targeting MMP9 and inhibiting APOE4/CypA/NF-κB axis.
Keyphrases
- blood brain barrier
- cerebral ischemia
- signaling pathway
- subarachnoid hemorrhage
- oxidative stress
- cell migration
- diabetic rats
- high glucose
- cognitive decline
- lps induced
- cancer therapy
- pi k akt
- high fat diet
- brain injury
- drug induced
- gene expression
- drug delivery
- adipose tissue
- inflammatory response
- dna methylation
- skeletal muscle