DNA Sequencing of Small Bowel Adenocarcinomas Identifies Targetable Recurrent Mutations in the ERBB2 Signaling Pathway.

Liana AdamF Anthony San LucasRichard FowlerYao YuWenhui WuYulun LiuHuamin WangDavid MenterMichael T TetzlaffJoe EnsorGaniraju ManyamStefan T AroldChad HuffScott KopetzPaul ScheetMichael James Overman

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2018)

The in vitro and in vivo models of SBA developed here provide a valuable resource for understanding targetable mutations in this disease. Our findings support clinical efforts to target activating ERBB2 mutations in patients with SBA that harbor these alterations.

Keyphrases

signaling pathway
small bowel
tyrosine kinase
pi k akt
genome wide
epithelial mesenchymal transition
single cell
circulating tumor
gene expression
oxidative stress