Ultraviolet light and riboflavin accelerates red blood cell dysfunction in vitro and in a guinea pig transfusion model.
Jin Hyen BaekHye Kyung H ShinFei XuXiaoyuan ZhangMatthew C WilliamsYamei GaoJaroslav G VostalPaul W BuehlerCarlos VillaFelice D'AgnilloPublished in: Blood transfusion = Trasfusione del sangue (2024)
UVR-RBCs administered to guinea pigs increased markers of intravascular and extravascular hemolysis in a UV dose-dependent manner. This model may allow for the discrimination of RBC injury during testing of extensively processed RBCs intended for transfusion.