Chronic sleep fragmentation shares similar pathogenesis with neurodegenerative diseases: Endosome-autophagosome-lysosome pathway dysfunction and microglia-mediated neuroinflammation.
Yi XieLi BaMin WangSai-Yue DengSi-Miao ChenLi-Fang HuangMin ZhangWei WangFeng-Fei DingPublished in: CNS neuroscience & therapeutics (2019)
Chronic sleep fragmentation could initiate pathogenetic processes similar to the early stage of neurodegeneration, including dysfunction of endosome-autophagosome-lysosome pathway and microglia-mediated neuroinflammation. Our findings further strengthen the link between chronic sleep insufficiency and the initiation of neurodegeneration even if lack of genetic predisposition.
Keyphrases
- early stage
- sleep quality
- physical activity
- inflammatory response
- traumatic brain injury
- lipopolysaccharide induced
- oxidative stress
- lps induced
- neuropathic pain
- cognitive impairment
- living cells
- fluorescent probe
- radiation therapy
- spinal cord injury
- depressive symptoms
- copy number
- drug induced
- spinal cord
- rectal cancer
- blood brain barrier
- single molecule
- locally advanced