The therapeutic effect of silymarin and silibinin on depression and anxiety disorders and possible mechanism in the brain: A systematic review.
Sahar RostamianSaeid Heidari-SoureshjaniCatherine Mt SherwinPublished in: Central nervous system agents in medicinal chemistry (2023)
Silymarin and silibinin exert anti-depression and anxiolytic effects by regulating neurotransmitters, endocrine, neurogenesis, and immunologic systems. Therefore, as natural and complementary medicines, they can be used to reduce the symptoms of depression and anxiety; However, more clinical studies are needed in this field.