Positive Association Between Location of Melanoma, Ultraviolet Signature, Tumor Mutational Burden, and Response to Anti-PD-1 Therapy.
Léa DoussetFlorence PoizeauCaroline RobertSandrine MansardLaurent MortierCharline CaumontÉmilie RoutierAlain DupuyJacques RouanetMaxime BattistellaAnna GreliakDavid CappellenMarie-Dominique GalibertClara AllayousAlexandra LespagnolEmilie GérardInès KerneuzetSéverine RoyCaroline DutriauxJean-Philippe MerlioBeatrice VergierAlexa B SchrockJessica LeeSiraj M AliSolène-Florence Kammerer-JacquetCeleste LebbèMarie Beylot-BarryLise BoussemartPublished in: JCO precision oncology (2021)
Cumulative sun exposure related to skin location and molecular UV signature present on the metastatic site appear to be relevant biomarkers directly linked to TMB. Because TMB is not yet available to all for routine clinical use, the location of the primary melanoma in a sun-exposed area may play an important role in clinical decisions regarding therapeutic choice.