TSH and FT4 reference interval recommendations and prevalence of gestational thyroid dysfunction: quantification of current diagnostic approaches.
Joris A J OsingaArash DerakhshanUlla Feldt-RasmussenKun HuangTanja G M VrijkotteTuija MännistöJudit BassolsAbel López-BermejoAshraf AminorroayaMarina VafeiadiMaarten A C BroerenGlenn E PalomakiGhalia AshoorLiangmiao ChenXuemian LuPeter N TaylorFang-Biao TaoSuzanne J BrownGeorgiana SitorisLida ChatziBijay VaidyaPolina V PopovaElena A VasukovaMaryam KianpourEila SuvantoElena N GrinevaAndrew T HattersleyVictor J M PopScott McGill NelsonJohn P WalshKypros H NicolaidesMary E D'AltonKris Gustave PoppeLayal ChakerSofie BliddalTim I M KorevaarPublished in: The Journal of clinical endocrinology and metabolism (2023)
Alternative approaches to define RIs for TSH and FT4 in pregnancy result in considerable over- and underdiagnosis compared with population- and trimester-specific RIs. Additional strategies need to be explored to optimize identification of thyroid dysfunction during pregnancy.