Next-generation sequencing not superior to culture in periprosthetic joint infection diagnosis.

Beau J KildowSean P RyanRichard DanilkowiczAlexander L LazaridesColin PenroseMichael P BolognesiWilliam JiranekThorsten M Seyler

Published in: The bone & joint journal (2021)

In our series, NGS did not provide superior sensitivity or specificity results compared to culture. PCR has little utility as a standalone test for PJI diagnosis with a sensitivity of only 18.4%. Currently, several laboratory tests for PJI diagnosis should be obtained along with the overall clinical picture to help guide decision-making for PJI treatment. Cite this article: Bone Joint J 2021;103-B(1):26-31.

Keyphrases

decision making
bone mineral density
copy number
dna methylation
combination therapy
total hip arthroplasty
smoking cessation