Skeletal Muscle Adiposity and Lung Function Trajectory in the Severe Asthma Research Program (SARP).
Matthew C TattersallKristine E LeeNanae TsuchiyaFauzia OsmanClaudia E KorcarzKristin M HansenMichael C PetersJohn V FahyColin A LonghurstEleanor M DunicanSally E WentzelJoseph K LeaderElliot IsraelBruce D LevyMario CastroSerpil C ErzurumJason LempelWendy MooreEugene BleeckerBrenda R PhillipsDavid T MaugerEirc A HoffmanSean B FainScott B ReederRon L SorknessNizar N JarjourLoren C DenlingerMark L SchieblerPublished in: American journal of respiratory and critical care medicine (2022)
Asthmatic participants have lower PSMD, reflecting greater muscle fat infiltration. Baseline PSMD predicted lung function decline among females with asthma, but not males. These data support an important role of metabolic dysfunction in lung function decline.