Nanomechanical Hallmarks of Helicobacter pylori Infection in Pediatric Patients.
Piotr DeptułaŁukasz SuprewiczTamara DanilukAndrzej NamiotSylwia Joanna ChmielewskaUrszula DanilukDariusz LebensztejnRobert BuckiPublished in: International journal of molecular sciences (2021)
collected data suggest that nanomechanical properties of infected tissue might be considered as markers indicated H. pylori presence since infected tissues are softer than uninfected ones. At the cellular level, this mechanical response is at least partially mediated by cell cytoskeleton remodeling indicating that gastric cells are able to tune their mechanical properties when subjected to the presence of H. pylori products. Persistent fluctuations of tissue mechanical properties in response to H. pylori infection might, in the long-term, promote induction of cancer development.
Keyphrases
- helicobacter pylori infection
- atomic force microscopy
- induced apoptosis
- helicobacter pylori
- papillary thyroid
- single cell
- cell cycle arrest
- hiv infected
- gene expression
- cell therapy
- big data
- stem cells
- squamous cell
- oxidative stress
- machine learning
- cell death
- signaling pathway
- young adults
- mass spectrometry
- artificial intelligence
- lymph node metastasis
- high speed
- high resolution
- deep learning