VLK drives extracellular phosphorylation of EphB2 to govern the EphB2-NMDAR interaction and injury-induced pain.

Kolluru D SrikanthHajira ElahiPraveen ChanderHalley R WashburnShayne HasslerJuliet M MwirigiMoeno KumeJessica LoucksRohita ArjarapuRachel HodgeStephanie I ShiersIshwarya SankaranarayananHediye Erdjument-BromageThomas A NeubertZachary T CampbellRaehum PaikTheodore John PriceMatthew B Dalva

Published in: bioRxiv : the preprint server for biology (2024)

Synaptic protein-protein interactions and pain are regulated by the presynaptic release of the extracellular kinase VLK in the spinal cord.

Keyphrases

neuropathic pain
spinal cord
chronic pain
pain management
protein kinase
spinal cord injury
high glucose
drug induced
prefrontal cortex