Fine-mapping the MHC locus in juvenile idiopathic arthritis (JIA) reveals genetic heterogeneity corresponding to distinct adult inflammatory arthritic diseases.

A HinksJohn David BowesJ CobbH C AinsworthM C MarionM E ComeauM SudmanB Hannull nullM L BeckerJ F BohnsackP I W de BakkerJ P HaasM HazenD J LovellP A NigrovicE NordalM PunnaroA M RosenbergM RyggSamantha Louise SmithC A WiseV VidemL R WedderburnA YarwoodR S M YeungS PrahaladC D LangefeldS RaychaudhuriS D ThompsonW Thomson

Published in: Annals of the rheumatic diseases (2016)

The findings suggest the value of using genetic data in helping to classify the categories of this heterogeneous disease. Mapping JIA categories to adult counterparts could enable shared knowledge of disease pathogenesis and aetiology and facilitate transition from paediatric to adult services.

Keyphrases

juvenile idiopathic arthritis
healthcare
high resolution
disease activity
emergency department
intensive care unit
primary care
genome wide
childhood cancer
mental health
air pollution
copy number
single cell
rheumatoid arthritis
gene expression
dna methylation
young adults
artificial intelligence