Association of Complement Factors With Disability Progression in Primary Progressive Multiple Sclerosis.
Jan D LünemannHarald HegenLuisa Maria VillarKonrad RejdakAugusto Sao-AvilesPere Carbonell-MirabentJaume Sastre-GarrigaNeus Mongay-OchoaKlaus BerekSergio Martínez-YélamosFrancisco Pérez-MirallesAhmed AbdelhakFranziska BachhuberHayrettin TumaniJan N LyckeIgal RosensteinRoberto Alvarez-LafuenteTamara Castillo TriviñoDavid OtaeguiSara LlufriuYolanda BlancoAntonio J Sánchez LópezJuan Antonio Garcia MerinoNicolás FissoloLucia GutierrezJavier Villacieros-ÁlvarezEnric MonrealAdrián Valls-CarbóHeinz WiendlXavier MontalbanManuel Comabella LopezPublished in: Neurology(R) neuroimmunology & neuroinflammation (2024)
Proteins involved in the activation of early complement cascades play a role in disability progression as risk (elevated serum C3a/C3 ratio) or protective (elevated CSF C1q) factors after 6 or more years of follow-up in patients with PPMS. The protective effects associated with C1q levels in CSF may be related to its neuroprotective and anti-inflammatory properties.