VX-765 ameliorates inflammation and extracellular matrix accumulation by inhibiting the NOX1/ROS/NF-κB pathway in diabetic nephropathy.

Xiaokang WangTiesong WuHongyan MaXiaoling HuangKaiyuan HuangChunxiao YeShiping Zhu

Published in: The Journal of pharmacy and pharmacology (2021)

Our results demonstrated that VX-765 exerts favourable effects on DN via the simultaneous alleviation of systemic metabolic syndrome and down-regulating the renal NOX1/ROS/NF-κB pathway, suggesting that it has therapeutic potential for DN.

Keyphrases

extracellular matrix
diabetic nephropathy
reactive oxygen species
signaling pathway
metabolic syndrome
oxidative stress
lps induced
dna damage
cell death
pi k akt
nuclear factor
mouse model
uric acid
cardiovascular disease
immune response