Macrophage-Expressed Coagulation Factor 7 Promotes Adverse Cardiac Remodeling.

Venkata GarlapatiQi LuoJens PosmaMelania AluiaThan Son NguyenKristin GrunzMichael MolitorStefanie FingerGregory Harms Tobias Bopp Wolfram Ruf Philip Wenzel

Published in: Circulation research (2024)

Extravascular TF-F7-PAR2 complex signaling drives inflammatory macrophage polarization in ischemic heart disease. Targeting this signaling complex for specific therapeutic macrophage reprogramming following MI attenuates cardiac fibrosis and improves cardiovascular function.

Keyphrases

left ventricular
adipose tissue
oxidative stress
cancer therapy