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Neuraminidase is a host-directed approach to regulate neutrophil responses in sepsis and COVID-19.

Rodrigo de Oliveira FormigaFlávia C AmaralCamila F SouzaDaniel A G B MendesCarlos W S WanderleyCristina B LorenziniAdara A SantosJuliana AntôniaLucas F FariaCaio C NataleNicholas M PaulaPriscila C S SilvaFernanda R FonsecaLuan AiresNicoli HeckMárick R StarickCelso M Queiroz-JuniorFelipe Rocha da Silva SantosFilipe R O de SouzaVivian V CostaShana P C BarrosoAlexandre MorrotJohan Van WeyenberghRegina SordiFrederico Alisson-SilvaFernando de Queiroz CunhaEdroaldo L RochaSylvie Chollet-MartinMaria Margarita Hurtado-NedelecClémence MartinPierre-Régis BurgelDaniel S MansurRosemeri MauriciMatthew S MacauleyAndré BáficaVéronique Witko-SarsatFernando Spiller
Published in: British journal of pharmacology (2022)
These findings suggest that interplay of NEU1-MMP-9 induces neutrophil overactivation. In vivo, NEU may serve as a host-directed target to dampen neutrophil dysfunction during severe infections.
Keyphrases
  • coronavirus disease
  • sars cov
  • acute kidney injury
  • intensive care unit
  • oxidative stress
  • early onset
  • septic shock
  • respiratory syndrome coronavirus