Comparison of microfluidic platforms for the enrichment of circulating tumor cells in breast cancer patients.
Constantin SajdikEva SchusterBarbara HolzerMichael KrainerChristine DeutschmannStefan PeterMaximilian MarholdRobert ZeillingerEva ObermayrPublished in: Breast cancer research and treatment (2022)
The Parsortix® system offers both reasonable recovery of tumor cells and depletion of contaminating leukocytes when the single-step separation using the GEN3D6.5 cassette is employed. Careful selection of suitable markers and cut-off thresholds is an essential point for the subsequent molecular analysis of the enriched cells.