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Comparison of microfluidic platforms for the enrichment of circulating tumor cells in breast cancer patients.

Constantin SajdikEva SchusterBarbara HolzerMichael KrainerChristine DeutschmannStefan PeterMaximilian MarholdRobert ZeillingerEva Obermayr
Published in: Breast cancer research and treatment (2022)
The Parsortix® system offers both reasonable recovery of tumor cells and depletion of contaminating leukocytes when the single-step separation using the GEN3D6.5 cassette is employed. Careful selection of suitable markers and cut-off thresholds is an essential point for the subsequent molecular analysis of the enriched cells.
Keyphrases
  • circulating tumor cells
  • induced apoptosis
  • circulating tumor
  • cell cycle arrest
  • cell death
  • high throughput
  • single molecule
  • single cell
  • mass spectrometry
  • cell proliferation
  • cell free