Assessment of the effect of therapy in a rat model of glioblastoma using [18F]FDG and [18F]FCho PET compared to contrast-enhanced MRI.

Julie Bolcaen Benedicte DescampsKarel DeblaereFilip De VosTom BoterbergGiorgio HallaertCaroline Van den BroeckeChristian VanhoveIngeborg Goethals

Published in: PloS one (2021)

Both MRI and particularly delayed [18F]FDG PET were able to detect early treatment responses in GB rats, whereas, in this study this was not possible using [18F]FCho PET. Further comparative studies should corroborate these results and should also include (different) amino acid PET tracers.

Keyphrases

contrast enhanced
positron emission tomography
computed tomography
pet ct
pet imaging
magnetic resonance imaging
diffusion weighted
diffusion weighted imaging
magnetic resonance
amino acid
dual energy
stem cells
combination therapy