LC3A-mediated autophagy regulates lung cancer cell plasticity.
Chia-Cheng MiaoWen HwangLing-Yi ChuLi-Hao YangCam-Thu HaPei-Yu ChenMing-Han KuoSheng-Chieh LinYa-Yu YangShuang-En ChuangChia-Cherng YuShien-Tung PanMou-Chieh KaoChuang-Rung ChangYu-Ting ChouPublished in: Autophagy (2021)
ATG14: autophagy related 14; CDH2: cadherin 2; ChIP-qPCR: chromatin immunoprecipitation quantitative polymerase chain reaction; CQ: chloroquine; ECAR: extracellular acidification rate; EMT: epithelial-mesenchymal transition; EPCAM: epithelial cell adhesion molecule; MAP1LC3A/LC3A: microtubule associated protein 1 light chain 3 alpha; MAP1LC3B/LC3B: microtubule associated protein 1 light chain 3 beta; MAP1LC3C/LC3C: microtubule associated protein 1 light chain 3 gamma; NDUFV2: NADH:ubiquinone oxidoreductase core subunit V2; OCR: oxygen consumption rate; ROS: reactive oxygen species; RT-qPCR: reverse-transcriptase quantitative polymerase chain reaction; SC: scrambled control; shRNA: short hairpin RNA; SNAI2: snail family transcriptional repressor 2; SOX2: SRY-box transcription factor 2; SQSTM1/p62: sequestosome 1; TGFB/TGF-β: transforming growth factor beta; TOMM20: translocase of outer mitochondrial membrane 20; ZEB1: zinc finger E-box binding homeobox 1.
Keyphrases
- epithelial mesenchymal transition
- transforming growth factor
- transcription factor
- simultaneous determination
- cell adhesion
- signaling pathway
- mass spectrometry
- cell death
- reactive oxygen species
- liquid chromatography
- oxidative stress
- gene expression
- dna binding
- solid phase extraction
- high density
- high throughput
- endoplasmic reticulum stress
- long non coding rna
- binding protein
- tandem mass spectrometry
- single cell
- bone marrow
- high resolution mass spectrometry